This database contains expertly curated molecular and biological information on genes proven to affect the outcome of pathogen-host interactions. Information is also given on the target sites of some anti-infective chemistries.
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Current release
Current release
Table No. of records
Genes 3152
Interactions 4530
Pathogens 188
Hosts 128
Diseases 267
References 1606


Version 3.7
Table No. of records
Genes 3369
Interactions 4792
Pathogens 225
Hosts 132
Diseases 261
References 1693


Version 3.6
Table No. of records
Genes 2875
Interactions 4102
Pathogens 166
Hosts 110
Diseases 181
References 1243


Version 3.5
Table No. of records
Genes 2434
Interactions 3152
Pathogens 109
Hosts 92
Diseases 108
References 1049


Version 3.4
Table No. of records
Genes 2433
Interactions 3151
Pathogens 109
Hosts 92
Diseases 107
References 1049


Version 3.3
Table No. of records
Genes 1065
Interactions 1335
Pathogens 97
Hosts 76
Diseases 64
References 720
Version 3.8 July 1st 2015
  • Bugfixes and inclusion of additional Oomycete effectors






Past releases:
Version 3.7 May 9th 2015
  • 494 additional genes tested in 690 interactions from 450 references




Version 3.6 May 6th 2014
  • 441 additional genes tested in 950 interactions from 194 references
  • XML download of database provided. The tabular file provided allows to set up a BLAST database.
  • The database contains six species with two physiological races each. The actual number of species in PHI-base is 160 species.




Version 3.5 November 4th 2013
  • Outlinks to UniProtKB, NCBI and EMBL provided
  • Updated Tabular file for all PHI-base genes with valid UniprotKB, NCBI or EMBL accession can be downloaded






Version 3.4 February 12th 2013
  • Major increase in gene content (1355 additional genes) from 323 additional references
  • The OXL (XML) download file withdrawn








Version 3.3 January 10th 2012
  • Update of web pages






Version 3.2 December 14th 2009
  • New entries
  • Bugfixes for some sequence accessions
Version 3.1 April 1st 2008
  • Improvements for some entries and sequence downloads
Version 3.0 September 13th 2007
  • New entries
  • Information on anti-infective tagets
  • OXL (XML) export
  • Selective export in FASTA format
  • DOIs for direct linkout to publications
Version 2.31 January 25th 2007
  • Bugfixes for some sequence accessions
Version 2.3 December 22nd 2006
  • New entries: information for some bacterial genes now available
  • Links provided for GO and EC databases for most entries
  • Searchable GO terms and EC annotations
  • Experimental evidence codes are provided in the details page for most entries
  • Information on the effect of double gene mutants
  • Mapping list PHI-base accessions to EMBL identifiers
Version 2.2 June 2nd 2006
  • New entries
  • Definition and classification of phenotypes
  • Search by phenotype added to 'Advanced Serach' panel
  • Support of linkouts to UniProt database
  • Missing sequences added to downloadable FASTA files
  • Revised format of sequences
Version 2.1 October 3rd 2005
  • New entries
  • Updated phenotype information for some entries (pre/post penetration)
  • Links provided to PubMed for all entries
  • Information presented for each individual gene-host interaction
  • Abbreviations replaced with full text
  • Links provided for GO and EC databases for some entries
Version 2.0 August 22nd 2005
  • New web interface
  • Direct links to Pubmed
  • FASTA downloadable files
Version 1.0 May 4th 2005
  • 379 genes
  • Experimental host verified and updated for all entries
  • Links provided to PubMed for some entries
Version: 3.8 Last revision: 01/07/15
PHI-base is a National Capability funded by Biotechnology and Biological Sciences Research Council (BBSRC, UK) and is being developed and maintained by scientists at Rothamsted Research.
PHI-base celebrates its 10th year anniversary.